Getting prospects to respond to cold emails can feel like shouting into the void. But with the right sequence strategy, you can start booking quality meetings within just two weeks. The secret lies in creating a systematic approach that builds trust, demonstrates value, and makes it easy for prospects to say yes.
Start with laser-focused targeting
Before you write a single word, know exactly who you’re talking to. Generic blasts are dead. Your ideal prospects should share specific traits: company size, industry, job title, recent funding rounds, or tech stack.
- Build buyer personas beyond demographics – focus on challenges, tools, and preferred content sources.
- Use website visitor identification tools to find warm leads already showing interest.
Craft compelling subject lines that get opened
Your subject line decides if your email is opened or trashed.
- Avoid salesy phrases (“Amazing opportunity”).
- Reference specifics (“Saw your expansion into Manchester”).
- Keep under 50 characters for mobile optimisation.
- Test different styles: questions (“Struggling with lead generation?”) or benefits (“3 ways to reduce churn by 40%”).
Structure your 5-email sequence for maximum impact
A 14-day sequence needs timing + variety.
Email 1 (Day 1): Value Introduction
Show insight into their business or industry, highlight a challenge, hint at your solution. Under 100 words, one CTA.
Email 2 (Day 4): Social Proof
Share a case study with numbers to build credibility.
Email 3 (Day 8): Helpful Resource
Offer value: report, checklist, or tool. Position yourself as helpful.
Email 4 (Day 11): Direct Value Proposition
Explain your solution and request a meeting with suggested times.
Email 5 (Day 14): Final Touch
Polite breakup email. Keep the door open. Many prospects reply here.
Personalise without being creepy
Go beyond first names. Reference relevant news, trends, or mutual connections.
Good: “I noticed you opened a new office in Edinburgh.”
Bad: “I saw from LinkedIn you went to university in Scotland.”
Use automation tools to enrich data, but always review before sending.

Time your emails strategically
- Best days: Tuesday–Thursday.
- Best times: 8–10am or 1–3pm.
- Avoid Mondays and Fridays.
- Space emails 3–4 days apart.
- Adjust timing based on engagement metrics.
Write like a human, not a robot
- Use a conversational tone.
- Avoid jargon and buzzwords.
- Keep paragraphs short with bullet points.
- Be specific: “I help SaaS reduce churn in 90 days” > “I help companies grow.”
Include clear, single calls-to-action
Each email = one goal.
- Be direct: if you want a meeting, ask for it.
- Suggest specific times to reduce back-and-forth.
- Use action-driven phrasing: “Let’s schedule a call” > “Would you be interested in discussing this someday?”
Track and optimise your results
Measure:
- Open rates
- Reply rates
- Meeting bookings
- Unsubscribes
Run A/B tests on subject lines, length, CTAs. Track which email in the sequence gets the best responses and refine accordingly.
The follow-up that seals the deal
When prospects reply:
- Send a calendar link immediately.
- Confirm details 24 hours before the call.
If they engage but don’t book, move them into a nurture sequence. They’re interested but not ready yet.
Cold email success takes testing and refinement. Start with this framework, optimise based on real data, and within 14 days you’ll be booking meetings that build a stronger sales pipeline.
Key principles: persistence without pushiness, value before asks, and treating prospects as people — not just email addresses.